JH Peever et al., NMDA Antagonism Reverses the Effect of Hypocretin-1 Page 1 EXCITATORY EFFECTS OF HYPOCRETIN-1 (OREXIN-A) IN THE TRIGEMINAL MOTOR NUCLEUS ARE REVERSED BY NMDA ANTAGONISM
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چکیده
Running Title: NMDA Antagonism Reverses the Effect of Hypocretin-1.
منابع مشابه
Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism.
Hypocretin-1 and -2 (Hcrt-1 and -2, also called orexin-A and -B) are newly identified neuropeptides synthesized by hypothalamic neurons. Defects in the Hcrt system underlie the sleep disorder narcolepsy, which is characterized by sleep fragmentation and the involuntary loss of muscle tone called cataplexy. Hcrt neurons project to multiple brain regions including cranial and spinal motor nuclei....
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Hypocretins/orexins are primary excitatory neuropeptides located exclusively in neurons of the lateral hypothalamic area, which send projections to most monoaminergic nuclei. It has been reported that i.c.v. injection of hypocretin 1 (orexin A) enhances wakefulness in rats and mice. The present work was carried out to examine the roles of hypocretins in nociception in mice. The presence of robu...
متن کاملRole of hypocretin-1,2 (orexin A and B) in pain perception
Hypocretins/orexins are primary excitatory neuropeptides located exclusively in neurons of the lateral hypothalamic area, which send projections to most monoaminergic nuclei. It has been reported that i.c.v. injection of hypocretin 1 (orexin A) enhances wakefulness in rats and mice. The present work was carried out to examine the roles of hypocretins in nociception in mice. The presence of robu...
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Hypocretin/orexin acts pharmacologically in the hypothalamus to stimulate stress hormone secretion at least in part by an action in the hypothalamic paraventricular nucleus, where the peptide's receptors have been localized. In addition, orexin acts in the brain to increase sympathetic tone and, therefore, mean arterial pressure and heart rate. We provide evidence for the role of endogenously p...
متن کاملDiurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors.
Diurnal release of the orexin neuropeptides orexin-A (Ox-A, hypocretin-1) and orexin-B (Ox-B, hypocretin-2) stabilises arousal, regulates energy homeostasis and contributes to cognition and learning. However, whether cellular correlates of brain plasticity are regulated through orexins, and whether they do so in a time-of-day-dependent manner, has never been assessed. Immunohistochemically we f...
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تاریخ انتشار 2003